Adequate Time and Staffing

The IC process is resource-intensive. It is sort of a "tax on research". Once you have invested in writing the ICD; developing protocols for "consenting" (responsible RTM identified, paperwork available, environment defined); and training your RTM in the IC process, you have paid most of these costs. But personnel, time, and space will still be needed to carry the project to completion. These are expensive resources. Your grant will pay for some, but departmental resources may be needed. Once you start the research, you are committed to certain aspects, the IC process being the first among them. Legally, you must fulfill your IC obligations, even if you don't think you have the resources to comfortably do so. Before you make the decision to start (with its implicit commitment of resources), it is wise to confirm that you actually have access to the resources needed.